Inflammation. Disc Degeneration. There is a connection. Inflammation acts as the body’s response system to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to restore itself to normal before the harm was achieved. Lombardy Chiropractic Clinic is always amazed at how the body takes care of itself! Lombardy Chiropractic Clinic sees its Augusta chiropractic care as the body’s partner in healing particularly when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to help the body. Melatonin is one nutritional tool that is showing value by interrupting the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are related to intervertebral disc degeneration. (1) IL-1 β actually promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body controls itself down to the cellular level via autophagy, the natural process during which the body’s cells clear out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin enhanced autophagy and lessened the degradation of the disc’s extracellular matrix (technically indicated by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The final conclusion was that melatonin prevents intervertebral disc degeneration by promoting autophagy. (3) Wow. Lombardy Chiropractic Clinic is encouraged by this research to see just how well melatonin can work for Augusta back pain related to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common condition seen at Lombardy Chiropractic Clinic making positive news like this quite rousing. A recent study explained how melatonin could modulate the extracellular matrix of the disc remodeling process initiated by IL-1 β. Additionally, melatonin reduced the inflammatory cell collection and reduced the release of connected inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery that melatonin disrupted the IL-1B feedback loop, researchers suggested that melatonin may support the healing process of intervertebral discs after damage has already been done. (1) Lombardy Chiropractic Clinic will keep following the new research regarding the role inflammation has in Augusta disc degeneration and melatonin’s role in combatting it.
INFLAMMATION AND MELATONIN
The importance of melatonin in helping to slow or stop painful conditions due to inflammation is increasing. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other mechanisms is quite fitting. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by blocking the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland produces melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific influence on inflammation and disc degeneration is most attention-getting to Lombardy Chiropractic Clinic and our Augusta back pain patients.
CONTACT Lombardy Chiropractic Clinic
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management manages disc degeneration for relief of chronic low back pain in her patient.
Schedule your Augusta chiropractic appointment with Lombardy Chiropractic Clinic now. We can talk about how inflammation affects your back pain and how melatonin may help with the related disc degeneration.